2021 U.S. Open men’s odds, picks, predictions: Renowned tennis insider fading Novak Djokovic

Tennis: Wimbledon

The 2021 U.S. Open begins in late August in New York, with an interesting field on the men’s side. Several prominent players, including Roger Federer, 2016 champion Stan Wawrinka and 2020 champion Dominic Thiem, will not play. However, Novak Djokovic is the centerpiece and he is aiming for a record-breaking 21st grand slam title. He can also become the first player since 1969 to win all four men’s grand slam titles in the same year.

With his long-term dominance, Djokovic is currently the betting favorite at Caesars Sportsbook by a wide margin. He is listed at -150 in the latest 2021 U.S. Open odds, while Daniil Medvedev is listed at +400 as the closest challenger. Rafael Nadal was +700 in the pre-draw tennis odds, but he dropped out due to a foot injury. Before making any 2021 U.S. Open picks or tennis predictions, see what renowned tennis handicapper Sean Calvert has to say.

Calvert is the handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1, the last Australian title won by someone other than Djokovic or Federer.

In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1. And earlier in 2021, he nailed both of his bets for the Wimbledon men’s singles final: Djokovic to win three sets to one (+275) and Djokovic to win and both players to win a set (+130).

Now, Calvert has broken down the latest U.S. Open 2021 odds and released his coveted best bets to win it all. Head to SportsLine to see them.

Top 2021 U.S. Open predictions

One surprise Calvert is calling for at the U.S. Open 2021: He doesn’t like the value of Djokovic at -150. The 34-year-old is seen as a prohibitive favorite at -150, and he is looking to make history by winning a fourth straight grand slam title. 

The 2021 U.S. Open is missing some of the biggest names, including and Nadal. In fact, the tournament doesn’t have its defending champion for the second straight year, as Dominic Thiem is out of the field in 2021 after Nadal missed the U.S. Open due to pandemic-related concerns in 2020. 

There is also the built-in storyline of his pursuit of No. 21 overall, and Djokovic is in a tier of his own on the odds board. Still, Calvert has real questions about his level of fitness and position right now, with Djokovic not playing as much high-end tennis recently. That, combined with his Olympic loss and a talented field with good values down the board, paints a picture that an investment in Djokovic may not be optimal. 

How to make 2021 U.S. Open picks

Instead, Calvert has locked in a stunning pick to win on a player going off higher than +6000. Find out who it is, and see all of Calvert’s picks and analysis, over at SportsLine.

So who wins the U.S. Open 2021? Which massive long shot stuns the tennis world? Visit SportsLine now to see Sean Calvert’s coveted U.S. Open picks, all from the renowned tennis expert, and find out. 

2021 U.S. Open odds 

Novak Djokovic -150
Daniil Medvedev +400
Alexander Zverev +700
Stefanos Tsitsipas +900
Matteo Berrettini +1600
Jannik Sinner +2500
Andrey Rublev +2500
Milos Raonic +3300
Andy Murray +3300
Denis Shapovalov +3300
Aslan Karatsev +4000
Felix Auger-Aliassime +5000
Hubert Hurkacz +6600
Juan Martin del Potro +6600
Grigor Dimitrov +6600
Nick Kyrgios +6600
Sebastian Korda +6600
Pablo Carreno-Busta +6600
Alex De Minaur +6600
Karen Khachanov +8000
Roberto Bautista Agut +8000