2021 MLB odds, picks, best bets for June 25 from proven model: This four-way parlay pays more than 10-1

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Two of the best teams in baseball collide when the San Francisco Giants host their Bay Area rival Oakland A’s in the first game of a three-game series on Friday at Oracle Park in San Francisco. The surprising Giants (48-26) own the best record in baseball and have a 4½-game lead in the NL West. Meanwhile, the A’s (46-31) sit in second place in the AL West, two games behind the division-leading Astros. First pitch is at 9:45 p.m. ET.

The A’s are -111 money-line favorites in the latest A’s vs. Giants odds from William Hill Sportsbook, while the Giants are +101 underdogs. The game is one of 16 on Friday’s MLB schedule. Other matchups include the Dodgers trying to bounce back after being no-hit by the Cubs on Thursday night and the Phillies and Mets playing a doubleheader at Citi Field. Before making any A’s vs. Giants or any MLB picks, you need to see the latest predictions from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league’s last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It’s off to a sizzling start in 2021, going 100-74 on top-rated MLB money-line picks through 12 weeks, returning more than $1,200. Anyone following it has seen huge returns.

Now, the model has crunched the numbers for Friday’s MLB schedule and posted its best bets. Parlaying these four MLB picks will pay more than 10-1. Head to SportsLine to see the picks.

Top MLB picks for Friday, June 25

One of the picks is the Indians (+115) to beat the Twins at 8:10 p.m. ET. Cleveland (41-31) is in the thick of the division race in the AL Central, sitting in second place just two games behind the White Sox. Meanwhile, the Twins (31-43) have struggled this season and occupy the basement in the five-team AL Central.

On Friday the Indians will face a Minnesota pitching staff that will be forced to have a bullpen day because of an injury to Randy Dobnak. Danny Coulombe, a 31-year-old journeyman reliever, will be called up from St. Paul to make his first career major league start. The Twins bullpen has a 4.82 ERA, which ranks 24th in the majors.

How to make MLB predictions, parlays

The model has locked in three other MLB best bets, including a play on an American League underdog. You can see its MLB best bets for June 25 only at SportsLine.

So which MLB picks should you make on Friday for a shot at a return of 10-1? And which American League underdog do you need to be all over? Visit SportsLine now to see Friday’s MLB picks, all from the projection model that is off to a fast start in 2021, and find out.